General Cell Based Assays
Eurofins Discoverx PathHunter Human P2RY4 Activated GPCR Internalization Cell-Based Assay Kit (U2OS)
The PathHunter Human P2RY4 Stable Cell Line Activated GPCR Internalization Assay (U2OS) contains a stable clonal cell line used to measure P2RY4 (GPCR) internalization via early-endosome localization. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx cAMP Hunter™ Human RXFP4 Gi Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Human RXFP4 Gi Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure RXFP4 (GPCR) activity via decreased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human TORC3 (CRTC3) Nuclear Translocation Cell-Based Assay Kit (U2OS)
The PathHunter Human TORC3 (CRTC3) Stable Cell Line Nuclear Translocation Assay (U2OS) contains a stable clonal cell line used to measure CRTC/CREB pathway activation via nuclear translocation of TORC3. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human Apelin (APJ Receptor) Activated GPCR Internalization Cell-Based Assay Kit (U2OS)
The PathHunter Human Apelin (APJ Receptor) Stable Cell Line Activated GPCR Internalization Assay (U2OS) contains a stable clonal cell line used to measure AGTRL1 (GPCR) internalization via early-endosome localization. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress c-Ret-GFRα2 Functional Assay, 2-Plate Kit. (93-0816E3CP16M)
The PathHunter eXpress c-Ret-GFRα2 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated c-Ret and GFRα2 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged c-Ret and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, GFRα2 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the cynomolgus version of the protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cayman Chemical 23-cGAMPsodIum salt 500ug
A second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA; contains a non-canonical 2’5’-phosphodiester bond; binds tightly to the adapter protein STING (Kd = 3.79 nM) and induces IFN-β mRNA expression (EC50 = 19.4 nM in L929 cells)
Revvity Health Sciences Inc HTRF Human H232 STING Binding Kit, 10,000 Assay Points
HTRF Human H232 STING Binding Kit, 10,000 Assay Points
Revvity Health Sciences Inc HTRF Human IL-2 Detection Kit Standard, 3 Vials
HTRF Human IL-2 Detection Kit Standard, 3 Vials
Revvity Health Sciences Inc HTRF HUman Total AKT Detection Kit, 10,000 Assay Points
HTRF HUman Total AKT Detection Kit, 10,000 Assay Points
Revvity Health Sciences Inc HTRF Human TNF-α / TNFR1 Binding Kit Standard
HTRF Human TNF-α / TNFR1 Binding Kit Standard
Revvity Health Sciences Inc HTRF Human AQ STING Binding Kit Standard
HTRF Human AQ STING Binding Kit Standard
Revvity Health Sciences Inc HTRF Human Total IκKβ Detection Kit, 500 Assay Points
HTRF Human Total IκKβ Detection Kit, 500 Assay Points
Revvity Health Sciences Inc HTRF Human H232 STING Binding Kit, 100,000 Assay Points
HTRF Human H232 STING Binding Kit, 100,000 Assay Points
Eurofins Discoverx PathHunter TrkB-P75 Bioassay Kit, 10-Plate. (93-0530Y3-00076)
The PathHunter TrkB-P75 Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. BDNF) induced dimerization of TrkB-P75 receptors. This product uses EFC technology. The included cell line overexpresses ProLink-tagged TrkB and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, P75. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. Upon ligand-induced dimerization of TrkB-P75, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.